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Factors that affect regulation of cGMP synthesis in vertebrate photoreceptors and their genetic link to human retinal degeneration.

Molecular and cellular biochemistry - 1 Jan 2002

Olshevskaya Elena V, Ermilov Alexandre N, Dizhoor Alexander M

Abstract excerpt

Cyclic GMP is essential for the ability of rods and cones to respond to the light stimuli. Light triggers hydrolysis of cGMP and stops the influx of sodium and calcium through the cGMP-gated ion channels. The consequence of this event is 2-fold: first, the decrease in the inward sodium current plays the major role in an abrupt hyperpolarization of the cellular membrane; secondly, the decrease in the Ca2+ influx...

Topics

Animals
Calcium
Calcium-Binding Proteins
Cyclic GMP
Guanylate Cyclase
Guanylate Cyclase-Activating Proteins
Humans
Mutation
Photoreceptor Cells, Vertebrate
Retinal Degeneration

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PMID: 11952089

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