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Article

Mouse models to study GCAP functions in intact photoreceptors.

Advances in experimental medicine and biology - 1 Jan 2002

Mendez Ana, Chen Jeannie

Abstract excerpt

In photoreceptor cells cGMP is the second messenger that transduces light into an electrical response. Regulation of cGMP synthesis by Ca2+ is one of the key mechanisms by which Ca2+ exerts negative feedback to the phototransduction cascade in the process of light adaptation. This Ca2+ feedback to retinal guanylyl cyclases (Ret-GCs) is conferred by the guanylate cyclase-activating proteins (GCAPs). Mutations in...

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PMID: 12596933
DOI: 10.1007/978-1-4615-0121-3_22

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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