Article
Coagulation factor V Leiden mutation in sudden fatal pulmonary embolism and in a general northern European population sample.
Forensic science international - 6 Dec 1999
Kuismanen K, Savontaus M L, Kozlov A, Vuorio A F, Sajantila A
Abstract excerpt
The R506Q point mutation in the gene coding for coagulation factor V (Leiden mutation) is the major underlying defect in resistance to activated protein C (APC), which predisposes to venous thrombosis. The risk of deep vein thrombosis is clearly elevated in carriers of the mutation, but the risk for pulmonary embolism has not been demonstrated to be as high. The aim of our study was to determine the frequency of...
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