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Article

Activated protein C resistance caused by a common factor V mutation has a single origin.

Thrombosis research - 1 Feb 1997

Zöller B, Hillarp A, Dahlbäck B

Abstract excerpt

A point mutation (FV:R506Q) in the human coagulation factor V gene is associated with resistance to activated protein C and life-long increased risk of venous thrombosis. The mutation is common in populations of Caucasian origin but virtually absent among other populations. In this study of 140 healthy Swedish volunteers and 110 homozygotes for the FV:R506Q mutation, we determined the allele frequencies of the...

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Identifiers

PMID: 9058498
DOI: 10.1016/s0049-3848(97)00008-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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