Article
M385T polymorphism in the factor V gene, but not Leiden mutation, is associated with placental abruption in Finnish women.
Placenta - 1 Jan 2000
Jääskeläinen E, Toivonen S, Romppanen E-L, Helisalmi S, Keski-Nisula L, Punnonen K, Heinonen S
Abstract excerpt
This study determines whether genetic variability in the gene encoding factor V contributes to differences in susceptibility to placental abruption. Allele and genotype frequencies of three single nucleotide polymorphisms (SNPs) in the factor V gene leading to nonsynonymous changes (M385T in exon 8, and R485K and R506Q [Leiden mutation] in exon 10) were studied in 116 Caucasian women with placental abruption and...
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