Article
Hairpin-bisulfite PCR: assessing epigenetic methylation patterns on complementary strands of individual DNA molecules.
Proceedings of the National Academy of Sciences of the United States of America - 6 Jan 2004
Laird Charles D, Pleasant Nicole D, Clark Aaron D, Sneeden Jessica L, Hassan K M Anwarul, Manley Nathan C, Vary Jay C, Morgan Todd, Hansen R Scott, Stöger Reinhard
Abstract excerpt
Epigenetic inheritance, the transmission of gene expression states from parent to daughter cells, often involves methylation of DNA. In eukaryotes, cytosine methylation is a frequent component of epigenetic mechanisms. Failure to transmit faithfully a methylated or an unmethylated state of cytosine can lead to altered phenotypes in plants and animals. A central unresolved question in epigenetics concerns the...
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