Article
Epigenetic variation illustrated by DNA methylation patterns of the fragile-X gene FMR1.
Human molecular genetics - 1 Oct 1997
Stöger R, Kajimura T M, Brown W T, Laird C D
Abstract excerpt
Genomic methylation patterns of mammals can vary among individuals and are subject to dynamic changes during development. In order to gain a better understanding of this variation, we have analyzed patterns of cytosine methylation within a 200 bp region at the CpG island of the human FMR1 gene fr...
Topics
- Alleles
- Base Sequence
- Chromosome Aberrations
- Cloning, Molecular
- CpG Islands
- Cytosine
- DNA
- DNA Methylation
- Female
- Fragile X Mental Retardation Protein
- Fragile X Syndrome
- Genetic Variation
- Humans
- Male
- Molecular Sequence Data
- Nerve Tissue Proteins
- Polymerase Chain Reaction
- Promoter Regions, Genetic