Failure of thymidine kinase-negative herpes simplex virus to reactivate from latency following efficient establishment.

Abstract excerpt

Thymidine kinase-negative mutants of herpes simplex virus did not reactivate from latency in mouse trigeminal ganglia, even when their latent viral loads were comparable to those that permitted reactivation by wild-type virus. Thus, reduced establishment of latency does not suffice to account for the failure to reactivate.

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Herpes Simplex
• Share to Mice
• Share to Molecular Sequence Data