Article
Restricted expression of herpes simplex virus lytic genes during establishment of latent infection by thymidine kinase-negative mutant viruses.
Journal of virology - 1 Nov 1990
Kosz-Vnenchak M, Coen D M, Knipe D M
Abstract excerpt
Infection of cells by herpes simplex virus (HSV) can lead to either lytic, productive infection or nonlytic, latent infection. The factors influencing this infection pathway decision are largely unknown. Thymidine kinase-negative mutant viruses can establish latent infection in neurons of mouse t...
Topics
- Animals
- Cornea
- Gene Expression Regulation, Viral
- Genes, Viral
- Herpes Simplex
- In Vitro Techniques
- Mice
- Mutation
- Nucleic Acid Hybridization
- RNA, Viral
- Simplexvirus
- Thymidine Kinase
- Transcription, Genetic
- Trigeminal Ganglion
- Viral Structural Proteins