Investigation of herpes simplex virus type 1 (HSV-1) gene expression and DNA synthesis during the establishment of latent infection by an HSV-1 mutant, in1814, that does not replicate in mouse trigeminal ganglia.

Abstract excerpt

In previous studies, the herpes simplex virus type 1 (HSV-1) mutant, in1814, which lacks the trans-inducing function of Vmw65, did not replicate in the trigeminal ganglia of mice following corneal inoculation but did establish a reactivatable latent infection in the ganglia 12 to 24 h after ocular infection. Since in1814 did not replicate in vivo, the molecular events during the establishment phase of latent...

Topics

• Animals
• Blotting, Northern
• DNA Replication
• DNA, Viral
• Female
• Gene Expression Regulation, Viral
• Keratitis, Dendritic
• Mice
• Mutation
• Nucleic Acid Hybridization