Article
Replication, latent infection, and reactivation in neuronal culture with a herpes simplex virus thymidine kinase-negative mutant.
Virology - 1 Mar 1992
Wilcox C L, Crnic L S, Pizer L I
Abstract excerpt
Herpes simplex virus type 1 (HSV-1) mutant viruses lacking functional viral thymidine kinase activity are reported to be incapable of replication in neurons. To investigate the role of viral thymidine kinase (TK) activity in the HSV-1 infection of the neuron, we studied a thymidine kinase-negative (TK-) mutant virus engineered to eliminate TK function without affecting the other known transcripts encoded in this...
Topics
- Animals
- Base Sequence
- Blotting, Southern
- Cell Line
- Cornea
- Mice
- Mice, Inbred BALB C
- Molecular Sequence Data
- Mutation
- Neurons
- Simplexvirus
- Thymidine Kinase