Article
A herpes simplex virus type 1 mutant with a deletion immediately upstream of the LAT locus establishes latency and reactivates from latently infected mice with normal kinetics.
Journal of neurovirology - 1 Aug 1996
Maggioncalda J, Mehta A, Bagasra O, Fraser N W, Block T M
Abstract excerpt
The latency associated transcripts (LATs) are the only abundant viral gene products detected during latent herpes simplex virus (HSV) infection of peripheral nerves in animals and people. A LAT promoter has been identified and mutant viruses with lesions removing the promoter and surrounding regi...
Topics
- Animals
- Blotting, Northern
- Blotting, Southern
- Cells, Cultured
- Culture Techniques
- DNA, Viral
- Deoxyribonucleases, Type II Site-Specific
- Female
- Gene Deletion
- Genome, Viral
- Genotype
- Herpesviridae Infections
- Herpesvirus 1, Human
- Kinetics
- Mice
- Mice, Inbred BALB C
- Mutation
- Phenotype