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Article

Restrictions to the Adaptation of Influenza A Virus H5 Hemagglutinin to the Human Host

11 Dec 2003

Abstract excerpt

The binding specificities of a panel of avian influenza virus subtype H5 hemagglutinin (HA) proteins bearing mutations at key residues in the receptor binding site were investigated. The results demonstrate that two simultaneous mutations in the receptor binding site resulted in H5 HA binding in a pattern similar to that shown by human viruses. Coexpression of the ion channel protein, M2, from most avian and...

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PMID: 14671130
DOI: 10.1128/jvi.78.1.502-507.2004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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