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Changes in the hemagglutinin of H5N1 viruses during human infection – Influence on receptor binding

17 Sept 2013

Abstract excerpt

As avian influenza A(H5N1) viruses continue to circulate in Asia and Africa, global concerns of an imminent pandemic persist. Recent experimental studies suggest that efficient transmission between humans of current H5N1 viruses only requires a few genetic changes. An essential step is alteration of the virus hemagglutinin from preferential binding to avian receptors for the recognition of human receptors present...

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PMID: 24050651
DOI: 10.1016/j.virol.2013.08.010

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