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Article

CD40, but not CD40L, is required for the optimal priming of T cells and control of aerosol M. tuberculosis infection.

Immunity - 1 Dec 2003

Lazarevic Vanja, Myers Amy J, Scanga Charles A, Flynn JoAnne L

Abstract excerpt

CD40(-/-) mice succumbed to low-dose aerosol infection with M. tuberculosis due to deficient IL-12 production leading to impaired priming of IFN-gamma T cell responses. In contrast, CD40L(-/-) mice were resistant to M. tuberculosis. This asymmetry in outcome of infection between the two knockout strains is likely due to the existence of an alternative ligand for CD40. Both in vitro M. tuberculosis infection and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 14670300
DOI: 10.1016/s1074-7613(03)00324-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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