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Influence of phthiocerol dimycocerosate on CD4(+) T cell priming and persistence during Mycobacterium tuberculosis infection.

Tuberculosis (Edinburgh, Scotland) - 1 Jul 2016

Pinto Rachel, Nambiar Jonathan K, Leotta Lisa, Counoupas Claudio, Britton Warwick J, Triccas James A

Abstract excerpt

The characterisation of mycobacterial factors that influence or modulate the host immune response may aid the development of more efficacious TB vaccines. We have previously reported that Mycobacterium tuberculosis deficient in export of Phthiocerol Dimycocerosates (DIM) (MT103(ΔdrrC)) is more attenuated than wild type M. tuberculosis and provides sustained protective immunity compared to the existing BCG...

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Source

Identifiers

PMID: 27450001
DOI: 10.1016/j.tube.2016.04.001

Genes

APC
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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