Article
Skeletal development is regulated by fibroblast growth factor receptor 1 signalling dynamics.
Development (Cambridge, England) - 1 Jan 2004
Hajihosseini Mohammad K, Lalioti Maria D, Arthaud Sandrine, Burgar Helen R, Brown Jill M, Twigg Stephen R F, Wilkie Andrew O M, Heath John K
Abstract excerpt
Ligand-dependent signalling pathways have been characterised as having morphogen properties where there is a quantitative relationship between receptor activation and response, or threshold characteristics in which there is a binary switch in response at a fixed level of receptor activation. Here we report the use of a bacterial artificial chromosome (BAC)-based transgenic system in which a hypermorphic mutation...
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