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Article

Transabdominal testicular descent is disrupted in mice with deletion of insulinlike factor 3 receptor.

Journal of pediatric surgery - 1 Dec 2003

Tomiyama Hideki, Hutson John M, Truong Anne, Agoulnik Alexander I

Abstract excerpt

BACKGROUND: Several factors are implicated in transabdominal testicular descent, including insulinlike factor 3 (INSL3) hormone and Müllerian-inhibiting substance (MIS). A transgene insertional mutation found on chromosome 5 in the mouse, known as crsp, causes deletion of a transmembrane G protein-coupled receptor gene, Great, which is highly expressed in the gubernaculum. The authors describe here a detailed...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14666470
DOI: 10.1016/j.jpedsurg.2003.08.047

Genes

INSL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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Transabdominal testicular descent is disrupted in mice with deletion of insulinlike factor 3 receptor.PMID 14666470Read ↗

Targeted disruption of the Insl3 gene causes bilateral cryptorchidism.Semantic proximity Read ↗

Suppression of Insulin-Like3 Receptor Reveals the Role of β-Catenin and Notch Signaling in Gubernaculum DevelopmentSemantic proximity Read ↗

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Insulin-Like 3 Signaling Is Important for Testicular Descent but Dispensable for Spermatogenesis and Germ Cell Survival in Adult Mice1Semantic proximity Read ↗

Insulin‐like 3 signalling in testicular descentSemantic proximity Read ↗

Loss of Insl3: a potential predisposing factor for testicular torsion.Semantic proximity Read ↗

Mutations of the GREAT gene cause cryptorchidismSemantic proximity Read ↗

INSL3/RXFP2 Signaling in Testicular DescentSemantic proximity Read ↗

GREAT/LGR8 is the only receptor for insulin-like 3 peptide.Semantic proximity Read ↗

The Overexpression of the<i>Insl3</i>in Female Mice Causes Descent of the OvariesSemantic proximity Read ↗

Insulin-like 3/relaxin-like factor gene mutations are associated with cryptorchidism.Semantic proximity Read ↗

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