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Article

Reactive-site mutants of N-TIMP-3 that selectively inhibit ADAMTS-4 and ADAMTS-5: biological and structural implications.

The Biochemical journal - 1 Oct 2010

Lim Ngee H, Kashiwagi Masahide, Visse Robert, Jones Jonathan, Enghild Jan J, Brew Keith, Nagase Hideaki

Abstract excerpt

We have reported previously that reactive-site mutants of N-TIMP-3 [N-terminal inhibitory domain of TIMP-3 (tissue inhibitor of metalloproteinases 3)] modified at the N-terminus, selectively inhibited ADAM17 (a disintegrin and metalloproteinase 17) over the MMPs (matrix metalloproteinases). The p...

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Identifiers

PMID: 20645923
DOI: 10.1042/BJ20100725
PMCID: PMC3003256

Genes

ADAM17

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20645923-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Reactive-site mutants of N-TIMP-3 that selectively inhibit ADAMTS-4 and ADAMTS-5: biological and structural implications.PMID 20645923Read ↗

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