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Article

Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degeneration.

Redox biology - 1 Oct 2016

Carlson Bradley A, Tobe Ryuta, Yefremova Elena, Tsuji Petra A, Hoffmann Victoria J, Schweizer Ulrich, Gladyshev Vadim N, Hatfield Dolph L, Conrad Marcus

Abstract excerpt

The selenoenzyme glutathione peroxidase 4 (Gpx4) is an essential mammalian glutathione peroxidase, which protects cells against detrimental lipid peroxidation and governs a novel form of regulated necrotic cell death, called ferroptosis. To study the relevance of Gpx4 and of another vitally important selenoprotein, cytosolic thioredoxin reductase (Txnrd1), for liver function, mice with conditional deletion of...

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Identifiers

PMID: 27262435
DOI: 10.1016/j.redox.2016.05.003
PMCID: PMC4900515

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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