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Article

Hepatic selenoprotein P (SePP) expression restores selenium transport and prevents infertility and motor-incoordination in Sepp-knockout mice.

The Biochemical journal - 1 Feb 2008

Renko Kostja, Werner Margarethe, Renner-Müller Ingrid, Cooper Trevor G, Yeung Ching Hei, Hollenbach Birgit, Scharpf Marcus, Köhrle Josef, Schomburg Lutz, Schweizer Ulrich

Abstract excerpt

SePP (selenoprotein P) is central for selenium transport and distribution. Targeted inactivation of the Sepp gene in mice leads to reduced selenium content in plasma, kidney, testis and brain. Accordingly, activities of selenoenzymes are reduced in Sepp(-/-) organs. Male Sepp(-/-) mice are infertile. Unlike selenium deficiency, Sepp deficiency leads to neurological impairment with ataxia and seizures....

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Identifiers

PMID: 17961124
DOI: 10.1042/BJ20071172

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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