Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Selective restoration of the selenoprotein population in a mouse hepatocyte selenoproteinless background with different mutant selenocysteine tRNAs lacking Um34.

The Journal of biological chemistry - 9 Nov 2007

Carlson Bradley A, Moustafa Mohamed E, Sengupta Aniruddha, Schweizer Ulrich, Shrimali Rajeev, Rao Mahadev, Zhong Nianxin, Wang Shulin, Feigenbaum Lionel, Lee Byeong Jae, Gladyshev Vadim N, Hatfield Dolph L

Abstract excerpt

Novel mouse models were developed in which the hepatic selenoprotein population was targeted for removal by disrupting the selenocysteine (Sec) tRNA([Ser]Sec) gene (trsp), and selenoprotein expression was then restored by introducing wild type or mutant trsp transgenes. The selenoprotein populati...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glutathione Peroxidase
Share to Hepatocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Methylation

Share to RNA, Transfer, Amino Acid-Specific

Share to Selenium

Share to Selenoproteins

Share to Thioredoxins

Share to Uridine

Source

Identifiers

PMID: 17848557
DOI: 10.1074/jbc.M707036200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17848557-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Selective restoration of the selenoprotein population in a mouse hepatocyte selenoproteinless background with different mutant selenocysteine tRNAs lacking Um34.PMID 17848557Read ↗

Inhibition of selenocysteine tRNA[Ser]Sec aminoacylation provides evidence that aminoacylation is required for regulatory methylation of this tRNA.Semantic proximity Read ↗

A homozygous mutation in the human selenocysteine tRNA gene impairs UGA recoding activity and selenoproteome regulation by selenium.Semantic proximity Read ↗

Mutation in human selenocysteine transfer RNA selectively disrupts selenoprotein synthesis.Semantic proximity Read ↗

The selenocysteine tRNA STAF-binding region is essential for adequate selenocysteine tRNA status, selenoprotein expression and early age survival of mice.Semantic proximity Read ↗

Specific excision of the selenocysteine tRNA[Ser]Sec (Trsp) gene in mouse liver demonstrates an essential role of selenoproteins in liver function.Semantic proximity Read ↗

Mouse Models Targeting Selenocysteine tRNA Expression for Elucidating the Role of Selenoproteins in Health and DevelopmentSemantic proximity Read ↗

Human selenoprotein P and S variant mRNAs with different numbers of SECIS elements and inferences from mutant mice of the roles of multiple SECIS elements.Semantic proximity Read ↗

Selective removal of the selenocysteine tRNA [Ser]Sec gene (Trsp) in mouse mammary epithelium.Semantic proximity Read ↗

Contrasting roles of dietary selenium and selenoproteins in chemically induced hepatocarcinogenesis.Semantic proximity Read ↗

Methylation of the ribosyl moiety at position 34 of selenocysteine tRNA[Ser]Sec is governed by both primary and tertiary structure.Semantic proximity Read ↗

Selenoproteins reduce susceptibility to DMBA-induced mammary carcinogenesis.Semantic proximity Read ↗

Secisbp2 is essential for embryonic development and enhances selenoprotein expression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.