Article
Selective restoration of the selenoprotein population in a mouse hepatocyte selenoproteinless background with different mutant selenocysteine tRNAs lacking Um34.
The Journal of biological chemistry - 9 Nov 2007
Carlson Bradley A, Moustafa Mohamed E, Sengupta Aniruddha, Schweizer Ulrich, Shrimali Rajeev, Rao Mahadev, Zhong Nianxin, Wang Shulin, Feigenbaum Lionel, Lee Byeong Jae, Gladyshev Vadim N, Hatfield Dolph L
Abstract excerpt
Novel mouse models were developed in which the hepatic selenoprotein population was targeted for removal by disrupting the selenocysteine (Sec) tRNA([Ser]Sec) gene (trsp), and selenoprotein expression was then restored by introducing wild type or mutant trsp transgenes. The selenoprotein population was partially replaced in liver with mutant transgenes encoding mutations at either position 34 (34T-->A) or 37...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.