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Article

Otx2 cell-autonomously determines dorsal mesencephalon versus cerebellum fate independently of isthmic organizing activity.

Development (Cambridge, England) - 1 Jan 2014

Di Giovannantonio Luca G, Di Salvio Michela, Omodei Daniela, Prakash Nilima, Wurst Wolfgang, Pierani Alessandra, Acampora Dario, Simeone Antonio

Abstract excerpt

During embryonic development, the rostral neuroectoderm is regionalized into broad areas that are subsequently subdivided into progenitor compartments with specialized identity and fate. These events are controlled by signals emitted by organizing centers and interpreted by target progenitors, which activate superimposing waves of intrinsic factors restricting their identity and fate. The transcription factor...

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Identifiers

PMID: 24335253
DOI: 10.1242/dev.102954

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Otx2 cell-autonomously determines dorsal mesencephalon versus cerebellum fate independently of isthmic organizing activity.PMID 24335253Read ↗

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