Article
The characterization of a zebrafish mid-hindbrain mutant, mid-hindbrain gone (mgo).
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Apr 2009
Shima Takaki, Znosko Wade, Tsang Michael
Abstract excerpt
The vertebrate mid-hindbrain boundary (MHB) is a crucial morphological structure required for patterning and neural differentiation of the midbrain and anterior hindbrain. We isolated a novel zebrafish mutant, MHB gone (mgo), that exhibited a defective MHB. Expression of engrailed3 in the prospective MHB was absent at the 1-somite stage, suggesting that initiation of the isthmic organizer was disrupted in mgo...
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