Article
Genetic polymorphisms and plasma levels of matrix metalloproteinases and their relationships with developing acute myocardial infarction.
Coronary artery disease - 1 Sept 2010
Ghaderian Sayyed Mohammad Hossein, Akbarzadeh Najar Reza, Tabatabaei Panah Akram Sadat
Abstract excerpt
OBJECTIVES: Matrix metalloproteinases (MMPs) play an important role in early atherosclerosis, plaque rupture, extracellular matrix remodeling, and myocardial infarction (MI). MMP gene polymorphisms contribute to the risk of developing cardiovascular disease. We designed to investigate the association of acute MI (AMI) with a polymorphism in the human MMP-1, 2, 3, and 9 genes in Iranian patients with AMI. METHODS:...
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