Article
Crystal structure of the catalytic domain of human ADAM33.
Journal of molecular biology - 2 Jan 2004
Orth Peter, Reichert Paul, Wang Wenyan, Prosise Winifred W, Yarosh-Tomaine Taisa, Hammond Gerald, Ingram Richard N, Xiao Li, Mirza Urooj A, Zou Jun, Strickland Corey, Taremi S Shane, Le Hung V, Madison Vincent
Abstract excerpt
Adam33 is a putative asthma susceptibility gene encoding for a membrane-anchored metalloprotease belonging to the ADAM family. The ADAMs (a disintegrin and metalloprotease) are a family of glycoproteins implicated in cell-cell interactions, cell fusion, and cell signaling. We have determined the crystal structure of the Adam33 catalytic domain in complex with the inhibitor marimastat and the inhibitor-free form....
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