Article
In Silico Evaluation of Nonsynonymous SNPs in Human ADAM33: The Most Common Form of Genetic Association to Asthma Susceptibility.
Computational and mathematical methods in medicine - 1 Jan 2022
Mohkam Milad, Golkar Nasim, Nabavizadeh Seyed Hesamodin, Esmaeilzadeh Hossein, Berenjian Aydin, Ghahramani Zahra, Golami Ahmad, Alyasin Soheila
Abstract excerpt
ADAM33 is a zinc-dependent metalloprotease of the ADAM family, which plays a vital biological role as an activator of Th2 cytokines and growth factors. Moreover, this protein is crucial for the normal development of the lung in the fetus two months after gestation leading to determining lung functions all over life. In this regard, mutations in ADAM33 have been linked with asthma risk factors. Consequently,...
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