Article
Patterns and functions of STAT activation during Drosophila embryogenesis.
Mechanisms of development - 1 Dec 2003
Li Jinghong, Li Wenjun, Calhoun Healani C, Xia Fan, Gao Fen-Biao, Li Willis X
Abstract excerpt
The JAK/STAT pathway mediates cytokine signaling in mammals and is involved in the function and development of the hematopoietic and immune systems. To investigate the biological functions of the JAK/STAT pathway during Drosophila development, we examined the tissue-specific localization of the tyrosine-phosphorylated, or activated form of Drosophila STAT, STAT92E. Here we show that during Drosophila embryonic...
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