Article
chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila.
Developmental cell - 20 Apr 2010
Flaherty Maria Sol, Salis Pauline, Evans Cory J, Ekas Laura A, Marouf Amine, Zavadil Jiri, Banerjee Utpal, Bach Erika A
Abstract excerpt
The Drosophila STAT transcription factor Stat92E regulates diverse functions, including organ development and stem cell self-renewal. However, the Stat92E functional effectors that mediate these processes are largely unknown. Here we show that chinmo is a cell-autonomous, downstream mediator of Stat92E that shares numerous functions with this protein. Loss of either gene results in malformed eyes and head...
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