Article
Localized JAK/STAT signaling is required for oriented cell rearrangement in a tubular epithelium.
Development (Cambridge, England) - 1 Jan 2003
Johansen Katherine A, Iwaki D David, Lengyel Judith A
Abstract excerpt
Rearrangement of cells constrained within an epithelium is a key process that contributes to tubular morphogenesis. We show that activation in a gradient of the highly conserved JAK/STAT pathway is essential for orienting the cell rearrangement that drives elongation of a genetically tractable model. Using loss-of-function and gain-of-function experiments, we show that the components of the pathway from ligand to...
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