Article
EGFR and KRAS mutation analysis in cytologic samples of lung adenocarcinoma enabled by laser capture microdissection.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Apr 2012
Chowdhuri Sinchita Roy, Xi Liqiang, Pham Trinh Hoc-Tran, Hanson Jeffrey, Rodriguez-Canales Jaime, Berman Arlene, Rajan Arun, Giaccone Giuseppe, Emmert-Buck Michael, Raffeld Mark, Filie Armando C
Abstract excerpt
The discovery of activating mutations in EGFR and KRAS in a subset of lung adenocarcinomas was a major advance in our understanding of lung adenocarcinoma biology, and has led to groundbreaking studies that have demonstrated the efficacy of tyrosine kinase inhibitor therapy. Fine-needle aspirates and other cytologic procedures have become increasingly popular for obtaining diagnostic material in lung carcinomas....
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