Article

A framework to detect positive selection using variant effect predictions reveals widespread adaptive evolution of human neurons

2025-09-12

Abstract excerpt

Detecting positive selection is essential to understanding evolution. Many methods to detect positive selection use simple classifications of genetic variants (e.g. synonymous/nonsynonymous). Here, we propose that these methods can be considered special cases of a more general framework to detect positive selection with any variant effect prediction method. Using evolutionary conservation and deep learning-based v...

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Literature Corpus work: 4e6ee810-42d6-5f81-99fa-cd50c04067b8
DOI: 10.1101/2025.09.11.675696

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