[Cognition impairment in the klotho gene mutant mice and oxidative stress].

Abstract excerpt

Klotho is a recently identified gene that is a very different type from those involved in previously described premature-aging syndromes and cell senescence. Although a high level of expression of the klotho gene was detected in the kidney and brain, little is known about the function of the klotho gene in the brain. Here we investigated the changes in mnemonic function accompanying aging in klotho mutant mice....

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