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<i>Plasmodium falciparum</i> antigenic variation. Mapping mosaic <i>var</i> gene sequences onto a network of shared, highly polymorphic sequence blocks

22 Apr 2008

Abstract excerpt

Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a potentially important family of immune targets, encoded by an extremely diverse gene family called var. Understanding of the genetic organization of var genes is hampered by sequence mosaicism that results from a long history of non-homologous recombination. Here we have used software designed to analyse social networks to visualize the...

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PMID: 18433451
DOI: 10.1111/j.1365-2958.2008.06248.x

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