Control of the endonuclease activity of type I restriction-modification systems is required to maintain chromosome integrity following homologous recombination.

Abstract excerpt

A type I restriction-modification enzyme will bind to an unmethylated target sequence in DNA and, while still bound to the target, translocate DNA through the protein complex in both directions. DNA breakage occurs when two translocating complexes collide. However, if type I restriction-modification systems bind to unmodified target sequences within the resident bacterial chromosome, as opposed to incoming...

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