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Macroautophagy is dispensable for intracellular replication of Legionella pneumophila in Dictyostelium discoideum

11 Nov 2003

Abstract excerpt

The Gram-negative bacterium Legionella pneumophila is a facultative intracellular pathogen of free-living amoebae and mammalian phagocytes. L. pneumophila is engulfed in phagosomes that initially avoid fusion with lysosomes. The phagosome associates with endoplasmic reticulum (ER) and mitochondria and eventually resembles ER. The morphological similarity of the replication vacuole to autophagosomes, and enhanced...

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PMID: 14651611
DOI: 10.1046/j.1365-2958.2003.03826.x

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