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Article

Dictyostelium macroautophagy mutants vary in the severity of their developmental defects.

The Journal of biological chemistry - 9 Apr 2004

Otto Grant P, Wu Mary Y, Kazgan Nevzat, Anderson O Roger, Kessin Richard H

Abstract excerpt

Macroautophagy is the major mechanism that eukaryotes use to recycle cellular components during stressful conditions. We have shown previously that the Atg12-Atg5 conjugation system, required for autophagosome formation in yeast, is necessary for Dictyostelium development. A second conjugation reaction, Aut7/Atg8 lipidation with phosphatidylethanolamine, as well as a protein kinase complex and a...

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PMID: 14736886
DOI: 10.1074/jbc.M311139200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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