Intracellular Replication of Mycobacterium marinum within Dictyostelium discoideum : Efficient Replication in the Absence of Host Coronin

Abstract excerpt

Mycobacterium marinum causes tuberculosis-like disease in fish and amphibians and has been used as a model mycobacterial species because of its rapid growth and less stringent containment requirements relative to other mycobacterial species. We demonstrate here that M. marinum grows within Dictyostelium discoideum cells, allowing the genetic analysis of host factors that may modulate the replication of...

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