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Article

Importance of p53 for cancer onset and therapy.

Anti-cancer drugs - 1 Aug 2006

Haupt Sue, Haupt Ygal

Abstract excerpt

Cancer predisposition, onset and therapeutic response can be critically determined by the integrity of the tumor suppressor p53. The majority of human cancers appear to exhibit either abnormal p53 or disrupted p53 activation pathways. Intervention to restore wild-type p53 activities is an attractive approach for cancer therapy. The manipulation of p53 and its targets is a challenging field that is still in its...

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Identifiers

PMID: 16926623
DOI: 10.1097/01.cad.0000217422.52208.fa

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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