Article
Pharmacological activation of p53 in cancer cells.
Current pharmaceutical design - 1 Jan 2011
Athar Mohammad, Elmets Craig A, Kopelovich Levy
Abstract excerpt
Tumor suppressor p53 is a transcription factor that regulates a large number of genes and guards against genomic instability. Under multiple cellular stress conditions, p53 functions to block cell cycle progression transiently unless proper DNA repair occurs. Failure of DNA repair mechanisms leads to p53-mediated induction of cell death programs. p53 also induces permanent cell cycle arrest known as cellular...
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