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Article

Cyclin E gene (CCNE) amplification and hCDC4 mutations in endometrial carcinoma.

The Journal of pathology - 1 Dec 2003

Cassia Raúl, Moreno-Bueno Gema, Rodríguez-Perales Sandra, Hardisson David, Cigudosa Juan C, Palacios José

Abstract excerpt

Cyclin E overexpression occurs in a subset of endometrial carcinomas (ECs), but the molecular mechanisms underlying this alteration remain to be established. The present study has analysed amplification of the cyclin E gene (CCNE) and mutation in hCDC4, the gene coding for the F-box protein, which tags phosphorylated cyclin E for proteosomal degradation, to ascertain whether these alterations might be responsible...

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Source

Identifiers

PMID: 14648662
DOI: 10.1002/path.1474

Genes

CGA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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