Article
Cyclin E involved in early stage carcinogenesis of esophageal adenocarcinoma by SNP DNA microarray and immunohistochemical studies.
BMC gastroenterology - 17 Apr 2014
Zhou Zhongren, Bandla Santhoshi, Ye Jiqing, Xia Yinglin, Que Jianwen, Luketich James D, Pennathur Arjun, Peters Jeffrey H, Tan Dongfeng, Godfrey Tony E
Abstract excerpt
BACKGROUND: Cyclin E is a cell cycle regulator which is critical for driving G1/S transition. Abnormal levels of cyclin E have been found in many cancers. However, the level changes of cyclin E in esophageal adenocarcinoma and its precancerous lesion have not been well studied. Here, we focus on the gene amplification and expression of cyclin E in these lesions, and aim to ascertain the relationship with...
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