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Targeting ofAdenovirus via Genetic Modification of the Viral Capsid Combined with aProteinBridge

25 Nov 2003

Abstract excerpt

A potential barrier to the development of genetically targeted adenovirus (Ad) vectors for cell-specific delivery of gene therapeutics lies in the fact that several types of targeting protein ligands require posttranslational modifications, such as the formation of disulfide bonds, which are not available to Ad capsid proteins due to their nuclear localization during assembly of the virion. To overcome this...

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PMID: 14645549
DOI: 10.1128/jvi.77.24.12931-12940.2003

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