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Article

A Strategy for Adenovirus Vector Targeting with a Secreted Single Chain Antibody

19 Dec 2009

Abstract excerpt

BACKGROUND: Successful gene therapy will require targeted delivery vectors capable of self-directed localization. In this regard, the use of antibodies or single chain antibody fragments (scFv) in conjunction with adenovirus (Ad) vectors remains an attractive means to achieve cell-specific targeting. However, a longstanding barrier to the development of Ad vectors with genetically incorporated scFvs has been the...

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PMID: 20027223
DOI: 10.1371/journal.pone.0008355

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