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Development of a generic adenovirus delivery system based on structure-guided design of bispecific trimeric DARPin adapters

19 Feb 2013

Abstract excerpt

Adenoviruses (Ads) have shown promise as vectors for gene delivery in clinical trials. Efficient viral targeting to a tissue of choice requires both ablation of the virus' original tropism and engineering of an efficient receptor-mediated uptake by a specific cell population. We have developed a series of adapters binding to the virus with such high affinity that they remain fully bound for >10 d, block its...

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PMID: 23431166
DOI: 10.1073/pnas.1213653110

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