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Genetic Targeting Strategies for Adenovirus

3 Sept 2005

Abstract excerpt

Adenovirus serotype 5 (Ad5) continues to be regarded as a gene delivery vehicle of high utility for a variety of clinical applications. However, targeting of the virus to alternate, non-native receptors has become a mandate for many gene therapy approaches, as inefficient viral transduction of target tissues has proven detrimental to the utility of Ad5. Thus, various targeting strategies have been endeavored to...

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PMID: 16196486
DOI: 10.1021/mp050045c

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