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Article

Antibody-Directed Targeting of Retroviral Vectors via Cell Surface Antigens

1 Sept 2001

Abstract excerpt

Targeted stable transduction of specific cells is a highly desirable goal for gene therapy applications. We report an efficient and broadly applicable approach for targeting retroviral vectors to specific cells. We find that the envelope of the alphavirus Sindbis virus can pseudotype human immunodeficiency virus type 1- and murine leukemia virus-based retroviral vectors. When modified to contain the Fc-binding...

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PMID: 11483746
DOI: 10.1128/jvi.75.17.8016-8020.2001

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