Article
Allelic variation at the C-reactive protein gene associates to both hand osteoarthritis severity and serum high sensitive C-reactive protein levels in the GARP study.
Annals of the rheumatic diseases - 1 Jun 2008
Bos S D, Suchiman H E D, Kloppenburg M, Houwing-Duistermaat J J, le Graverand M P Hellio, Seymour A B, Kroon H M, Slagboom P E, Meulenbelt I
Abstract excerpt
OBJECTIVE: To gain more insight into the role of genetic variation of the C-reactive protein (CRP) gene in serum CRP levels and osteoarthritis (OA). METHODS: Serum high sensitive CRP (S-HsCRP) levels were measured in the Genetics of osteoARthritis and Progression (GARP) study. Furthermore, to assess genetic variation of the CRP gene, genotypes of five tagging single nucleotide polymorphisms were assessed in the...
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