C-Reactive Protein Levels in Systemic Lupus Erythematosus Are Modulated by the Interferon Gene Signature and CRP Gene Polymorphism rs1205.

doi:10.3389/fimmu.2020.622326

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Article

C-Reactive Protein Levels in Systemic Lupus Erythematosus Are Modulated by the Interferon Gene Signature and CRP Gene Polymorphism rs1205.

Frontiers in immunology - 1 Jan 2020

Enocsson Helena, Gullstrand Birgitta, Eloranta Maija-Leena, Wetterö Jonas, Leonard Dag, Rönnblom Lars, Bengtsson Anders A, Sjöwall Christopher

Abstract excerpt

Objectives: Patients with systemic lupus erythematosus (SLE) often display modest elevations of C-reactive protein (CRP) despite raised disease activity and increased interleukin (IL-) 6. We asked to what extent IL-6 levels, the CRP polymorphism rs1205, and the type I interferon (IFN) gene signature affects the basal CRP levels in patients with SLE during a quiescent phase of the disease. Methods: CRP and IL-6...

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PMID: 33584722
DOI: 10.3389/fimmu.2020.622326
PMCID: PMC7876312

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