Article
A C-reactive protein promoter polymorphism is associated with type 2 diabetes mellitus in Pima Indians.
Molecular genetics and metabolism - 1 Feb 2003
Wolford Johanna K, Gruber Jonathan D, Ossowski Victoria M, Vozarova Barbora, Antonio Tataranni P, Bogardus Clifton, Hanson Robert L
Abstract excerpt
Linkage analysis has identified a susceptibility locus for type 2 diabetes mellitus (T2DM) on chromosome 1q21-q23 in several populations. Results from recent prospective studies indicate that increased levels of C-reactive protein (CRP), a marker of immune system activation, are predictive of diabetes, independent of adiposity. Because CRP is located on 1q21, we considered it a potential positional candidate gene...
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